Have you ever heard of the term magic mushrooms? This type of fungus can cause hallucinations, aka intoxication. Magic mushrooms are usually growing on cow dung. The most important substance in this mushroom is psilocybin. It has a hallucinogenic content called psilocybin. This substance acts on the central nervous system to confuse the user’s consciousness and emotions. Besides, the substances contained in these mushrooms will cause changes in thinking processes, loss of control, orientation, and depression. However, psilocybin is legalized in the US. The FDA approved psilocybin for use in psilocybin therapy, mostly in the form of DOSE THERAPY.
The FDA explains that this drug therapy is currently in a clinical trial period, and is called Breakthrough Therapy. Usually, the drug for Psilocybin Therapy is ordered by a drug company that believes that the psilocybin will be very effective and represents an improvement over existing depression therapies. Previous clinical research on psilocybin was carried out by Compass Pathways. Psilocybin is thought to treat several types of depression. Psilocybin treatment is used by patients who have had at least two different types of antidepressant treatment. Then clinical research on psilocybin was carried out by the company Usona Institute. The trial was conducted on 80 participants from seven different states in the United States, focusing on patients who have Major Depressive Disorder (MDD). In the United States alone, more than 17 million people experience MDD or depression that lasts more than two weeks. One dose of psilocybin has a direct effect on the brain and is thought to last long enough to rule out depressive symptoms.
The Usona Institute will conduct phase 2 trials in early 2021, followed by phase 3 trials thereafter. Available data prove that psilocybin contains clinical substances that bring significant changes and improvements to existing depression therapy. In March 2019, the FDA has also approved the use of psilocybin in a nasal spray depression treatment. The product used is Esketamine, but there has been no further research on how effective this drug is used for long-term antidepressants.